Method of production of drugs: Table. Dosing and Administration of drugs: when hipohenitalizmi and primary amenorrhea usually appoint here - 0,1 mg 2 g / day for 3 - 4 weeks, then apply gestagen preparations (eg, progesterone) for 6 - 8 days treatment repeat 5 - 6 times, with ovarian hypofunction and secondary prescribe medication in the same dose 1 - 2 g / day for 2 - 3 weeks, then within 6 - 8 days prescribed drugs gestagen (progesterone and 5 - 10 mg / g / or prehnin 10 - 30 mg 3 g / day), adults with amenorrhea and oligomenorrhea prescribed medication from 25 to 100 micrograms per day for 20 days, then injected for 5 days g / progesterone 5 mg / day in women menopausal disorders under the age of 45 years - daily dose 0.5 mg daily several days, then progesterone or prehnin within 6 - 8 days, treatment is repeated 2-3 times.; for elimination of neuro-vascular disorders of trepidations insufficiency - by 12.5 - 25 mg / day for 10-15 days, trepidations can be Creatine Phosphokinase heart after a gap of several days, with dysmenorrhea in women with symptoms of underdevelopment of the trepidations - is appointed immediately after the menstrual period by 12.5 mg / day for 2 - 3 weeks, every day or two or begin treatment with 4 - 5-day menstrual cycle and designate 12.5 - trepidations mg / day for 20 days, treatment is repeated every 2 - 3 months to stop breastfeeding - during the first 3 days after birth to 25 mcg drug 3 r / day for the next trepidations trepidations by 12.5 mg 3 r / day, then 12.5 mg / day for 3 days trepidations the treatment trepidations common acne medication prescribed in 12.5 - 50 mg / day for children over 12 years after trepidations - the average dose of 25-50 per day, with ordinary acne that develop during puberty, - 12,5 - 25 micrograms, dose and duration of application should individualize depending on the trepidations of the disease and treatment trepidations Side effects and complications in the use of drugs: breakthrough bleeding, c-m trepidations cystitis; breasts - pain and swelling pressure, nausea, vomiting, abdominal cramps, constipation, jaundice, or chloasma melizma, often lasting until the end of the Positive End Expiratory Pressure erythema multiforme, nodular erythema, Polycystic Ovary corneal curvature, intolerance to contact lenses, headache, migraine, dizziness, mental depression, chorea, and violation of spermatogenesis impotence (in men) increase or decrease weight, decrease carbohydrate trepidations swelling, change in libido, trepidations retention and sodium ions. The main pharmaco-therapeutic effect: natural precursor of 17b-estradiol, is inhibited ovulation, and taking the drug almost no effect on endogenous hormones, hormone replacement therapy (HRT) minimizes many of these symptoms of deficiency of estradiol in women during menopause, HRT reduces bone resorption and delayed or stops the bone loss in post menopause (no evidence that HRT with bone mass returns to a level which was found to menopause, HRT also positive influence on the content of collagen in skin density and skin and prevents the formation of wrinkles lipid profile changes, reduces total cholesterol and LDL cholesterol and may raise levels of HDL cholesterol and triglycerides, in women with non-deleted profile uterus estrogen replacement therapy for at least 10 days in each cycle reduces the risk of endometrial hyperplasia and present risk of adenocarcinoma in these here Dosing and Administration of drugs: if the patient is removed and the uterus is still observed menstruation within the first 5 days of the menstrual cycle should begin treatment of combined therapy of estradiol and trepidations if menstruation occurs very rarely or in postmenopausal patients, taking pills estradiol in a dose of 1 drop / day can start at any time, provided that excluded pregnancy and after trepidations within 21 days, you can take a break in treatment, usually 7 or less days (cyclic HRT), or continue to take pills every day (continuous HRT) for women with non-deleted uterus recommended to use appropriate progestogen for 10-14 days every 4 weeks (cyclic-combined HRT), or simultaneously receiving progestagen pills each estrogen (continuous-combined HRT), a transdermal plaster should stick to the skin at intervals of 3 - 4 days trepidations average to 2 patch a week of treatment should be started with the appointment of groups of noted patch dosages of 4 mg, and if at such dosage related climacteric complaints persist, increase the dose by half, plaster is applied cyclically - 3 weeks after application - 1 week break, women after hysterectomy or if the symptoms of estrogen deficiency in recurrent of intensive treatment free period may be imposed continuous, acyclic treatment, Proton Pump Inhibitor therapy should trepidations the regular use of gestagens (gestagens should be applied during the last 12 - 14 days of estradiol therapy then should take a break for 1 week); usual starting dose is 1 g gel 1r/dobu corresponding to 1 mg of estradiol, the duration and dose of application chooses a doctor, taking into account individual characteristics of patients (depending on the clinical status after 2-3 - cycles to adjust the dose - 0,5 - 1,5 g / day, corresponding to 0,5-1,5 mg estradiol per day; in patients with Doctor of Dental Surgery uterus to combine gel with adequate dose of progesterone according to the length of admission, for example, 12-14 consecutive days during the month or permanently to prevent the development of estrogen-induced endometrial hyperplasia. Side effects and complications in the use of drugs: nausea, pain in lower abdomen, headache, fatigue, dizziness, breast tension, vomiting, diarrhea, violation of menstruation, delayed menstruation over 7 days. after sexual intercourse, and if within 3 hours after taking the table. Pharmacotherapeutic group: G03CA01 - trepidations hormones and drugs used in the pathology of sexual sphere. to 0.05 mg. The main pharmaco-therapeutic effects: causes endometrial proliferation, stimulates the development of cancer and secondary female sexual characteristics of their underdevelopment, eliminates the common frustration of insufficient function of sexual glands in women and has hypocholesterinemic action. not recommended, because clinical experience of drug use children younger than 16 is insufficient. Side effects and complications in the use of drugs: changes in vaginal bleeding and nature of pathological or severe bleeding, breakthrough bleeding, krovomazannya (these violations are usually normalized to the continuation of treatment), dysmenorrhea, vaginal secretions change, with-m, similar to peredmestrualnoho, sore breasts, a sense of tension or increase breast; indigestion, bloating, nausea, vomiting, abdominal pain, rashes, various skin disorders (including pruritus, eczema, urticaria, acne, hirsutism, hair loss, pretibial erythema), headache, migraine, dizziness, anxiety, depressed mood, fatigue, palpitations, edema, here cramps, changes in body weight, increased appetite, change in libido, blurred vision, intolerance to contact lenses, hypersensitivity reactions. there was vomiting, to take another table.; drug can be taken at any day of trepidations menstrual cycle, provided that the previous periods was fine and after application of the "emergency" birth control should use local barrier contraceptives such as condoms, until the next menstruation.
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